Estradiol monotherapy

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Estradiol monotherapy is when one can achieve adequate androgen inhibition without the assistance of an antiandrogen. Although weak, estradiol has the ability on it's own to block production of testosterone. This may be possible to achieve through high-dose estrogen HRT (not recommended) or through the addition of a GnRH agonist (such as progesterone taken rectally). Some may be able to achieve this after taking certain antiandrogens for long enough, but this is a case-by-case basis and can't be guaranteed for everyone.