Finasteride

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Finasteride
Skeletal formula for Finasteride; a commonly prescribed 5α-Reductase inhibitor.
Drug class: 5α-Reductase inhibitor, Antiandrogen
Dosage range: Oral: 0.5–5 mg/day
Brand names: Propecia, Proscar, Finpecia
Elimination half-life Adults: 5–6 hours

Elderly: >8 hours

Finasteride
Skeletal formula for Finasteride; a commonly prescribed 5α-Reductase inhibitor.
Drug class: 5α-Reductase inhibitor, Antiandrogen
Dosage range: Oral: 0.5–5 mg/day
Brand names: Propecia, Proscar, Finpecia
Elimination half-life Adults: 5–6 hours

Elderly: >8 hours

Finasteride is a 5α-Reductase inhibitor.[1] 5α-Reductase is the enzyme responsible for converting testosterone into dihydrotestosterone (DHT), a form of testosterone that is 100x more potent. It is commonly prescribed to cis males to treat enlarged prostate, slow the rate of male pattern baldness, and help decrease the risk of prostate cancer. It has also been found to reduce excessive facial and/or body hair growth (hirsutism) in cis women.

It is commonly prescribed to transgender women as an antiandrogen to block the synthesis of DHT, which could potentially lead to less or even reverse-feminization in certain cases. It's recommended that you consult a doctor before incorporating finasteride in your HRT regimen, as there are several negative side effects associated with the drug and may be unnecessary.

Method of Action

Antiandrogen effects

Finasteride is a selective inhibitor of type II and III isoforms of the enzyme 5α-Reductase.[2] This reduces the creation of DHT from testosterone in hair follicles, skin, and the prostate gland anywhere between 60-90%. It will not completely block DHT's creation as it does not act upon 5α-Reductase type I isoenzyme. It's highly recommended that you use bicalutamide to assist in completely blocking the negative effects of DHT. If bicalutamide is not available, dutasteride has been found to reduce DHT levels in the entire body by more than 99%, but this medication comes with its own list of side effects.

Allopregnanolone and 3α-androstanediol

Allopregnanolone and 3α-androstanediol are both neurosteroids produced naturally with progesterone and DHT respectively. These activate the GABAA receptor in the brain. Finasteride inhibits the creation of neurosteroids and contributes to a reduction in GABAA, which has been known to lead to anxiety, depression, and sexual dysfunction.[3][4][5]

Side Effects

The use of finasteride may result in the following side effects...

  • Erectile dysfunction
  • Loss of libido
  • Ejaculatory disorders
  • Reduction in penis size
  • Reduced penis sensation
  • Muscular atrophy
  • Fatigue
  • Dry skin
  • Cognitive impairments/brain fog
  • Depression
  • Anxiety
  • Suicidal ideation
  • Gynecomastia

Dosage

The usual dose recommended is 0.5 to 1 mg daily via oral administration. Doctors may prescribe up to 5 mg daily, but this may be more than is necessary depending on your hormone levels. Hormone levels, specifically DHT, should be monitored through blood tests to ensure you are receiving the appropriate dosages of finasteride.

Topical finasteride is also prescribed to treat pattern hair loss and has shown a decrease in serum DHT levels. However, serum DHT inhibition using this method is less effective than the oral route.

Brand Names

The major brand names of finasteride are Propecia (1 mg), commonly prescribed for hair loss, and Proscar (5 mg), for enlarged prostate. Other brand names used for finasteride are Finpecia or Fincar.

Sources

Product Price Bulk Website Shipping
Finalo 1mg x 10 3.65€ 3.17€ UnitedPharmacies-NL (NL-Centric)
Finalo 1mg x 10 3.31£ 2.88£ UnitedPharmacies-UK (UK-Centric)
Finast 5mg x 30 22.72$ 20.45$ UnitedPharmacies (US-Centric)
Finast 5mg x 30 20.57€ 18.51€ UnitedPharmacies-NL (NL-Centric)
Finast 5mg x 30 18.68£ 16.81£ UnitedPharmacies-UK (UK-Centric)
Finast 5mg x 30 12.40$ 9.12$ WebOrderPharmacy Ships from India
Finasteride 5mg x 30 11.95$ Pilloid Ships from Russia
Finasteride 5mg x 30 11.95$ OTC-Online-Store Ships from Russia
Finax 1mg x 30 9.20$ 5.52$ WebOrderPharmacy Ships from India
Fincar 5mg x 30 17.24$ 14.90$ AllDayChemist Various fulfillment centers
Finpecia 1mg x 10 4.23$ 3.80$ UnitedPharmacies (US-Centric)
Finpecia 1mg x 30 28.75$ 16.50$ InHousePharmacy Ships from Vanuatu
Finpecia 1mg x 30 7.60$ 6.46$ AllDayChemist Various fulfillment centers
Finpros 5mg x 100 62.78€ EU-Aibolit Ships from EU
Novaride 5mg x 30 8.00$ Medicina Mexico Ships from Mexico
Penester 5mg x 90 55.82€ EU-Aibolit Ships from EU
Propecia 1mg x 28 87.85$ Amazon4Health Ships from Thailand
Proscar 5mg x 28 31.30€ Aphrodite's Ships from Portugal
Proscar 5mg x 28 30.00€ Shape Shifter Ships from Turkey
Proscar 5mg x 30 99.95$ Amazon4Health Ships from Thailand
Prosteride 5mg x 30 29.50$ 24.84$ InHousePharmacy Ships from Vanuatu


Alibaba

Finasteride can be purchased in tablet form through a variety of sources such as online pharmacies. However, it can also be purchased in bulk powdered form through vendors on websites such as Alibaba. From personal experience, Alibaba is substantially cheaper and some vendors will often go to great lengths to get your product to you by deliberately mislabelling packages in order to more easily get them through customs. We have personally had good luck with this particular vendor. It is also worth noting that in order to purchase products from these sites, you will need to personally contact the vendor and negotiate a price with them.

See also

External links

References

  1. Finasteride (Drugs.com) | https://www.drugs.com/monograph/finasteride.html#moreResources
  2. An overview on 5α-reductase inhibitors (ScienceDirect.com) | https://doi.org/10.1016/j.steroids.2009.10.005
  3. Finn, D.A., Beadles‐Bohling, A.S., Beckley, E.H., Ford, M.M., Gililland, K.R., Gorin‐Meyer, R.E. and Wiren, K.M. (2006), A New Look at the 5α‐Reductase Inhibitor Finasteride. CNS Drug Reviews, 12: 53-76. doi:10.1111/j.1527-3458.2006.00053.x
  4. Römer, B. and Gass, P. (2010), Finasteride‐induced depression: new insights into possible pathomechanisms. Journal of Cosmetic Dermatology, 9: 331-332. doi:10.1111/j.1473-2165.2010.00533.x
  5. Gunn Benjamin, Brown Adam, Lambert Jeremy, Belelli Delia (2011). "Neurosteroids and GABAA Receptor Interactions: A Focus on Stress" 131. DOI=10.3389/fnins.2011.00131