Gonadotropin-releasing hormone

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Gonadotropin-releasing hormone is a hormone produced in the HPG axis, specifically the hypothalamus, that releases luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

GnRH agonists, such as progesterone, can act as antiandrogens in those with testes or antiestrogens in those with ovaries. It accomplishes this by overstimulating the GnRH receptor in such a way that it desensitizes it, to the point where it becomes non-functional.[1] GnRH is normally released in pulses throughout the day, secreting LH and FSH consistently with each pulse. When GnRH agonists are continuously present, this results in excessive downregulation of the receptor and a complete loss of function.[1][2]

See also


  1. 1.0 1.1 Engel, J., Schally, A. Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone. Nat Rev Endocrinol 3, 157–167 (2007). https://www.nature.com/articles/ncpendmet0399
  2. Conn PM, Crowley WF (January 1991). "Gonadotropin-releasing hormone and its analogues". N. Engl. J. Med. 324 (2): 93–103. PMID 1984190. https://www.nejm.org/doi/full/10.1056/NEJM199101103240205